Skip to content

Join our Exclusive Subscription Offer: Save 30% on all Products Today!

  • All Products
  • Categories
    • Tailored For You
      • For Athletes
      • For Travelers
      • For Kids & Family
      • For Healthy Aging
      • For Beauty Lovers
      • For Wellness Enthusiasts
      • For Busy Professionals
    • Health Essentials
      • Immune Boosters
      • Energy & Vitality
      • Skin & Beauty Care
      • Respiratory Support
      • Gut Health & Digestion
      • Joint & Muscle Care
      • Sleep & Relaxation
    Anatolian Propolis Extract (A.P.E)®

    Anatolian Propolis Extract (A.P.E)®

    Shop All
    SKIN CARE

    SKIN CARE

    Shop All
  • Propolis
  • Royal Jelly
  • Raw Honey
  • Bee Bread & Pollen
  • Skincare
Log in
No account yet? Create Account
  • Twitter
  • Facebook
  • Pinterest
  • Instagram
  • YouTube
Close
  • All Products
  • Categories
    • Tailored For You
      • For Athletes
      • For Travelers
      • For Kids & Family
      • For Healthy Aging
      • For Beauty Lovers
      • For Wellness Enthusiasts
      • For Busy Professionals
    • Health Essentials
      • Immune Boosters
      • Energy & Vitality
      • Skin & Beauty Care
      • Respiratory Support
      • Gut Health & Digestion
      • Joint & Muscle Care
      • Sleep & Relaxation
  • Propolis
  • Royal Jelly
  • Raw Honey
  • Bee Bread & Pollen
  • Skincare
    Honey & Mixes

    Honey & Mixes

    Shop All
    Anatolian Propolis Extract (A.P.E)®

    Anatolian Propolis Extract (A.P.E)®

    Shop All
    SKIN CARE

    SKIN CARE

    Shop All
    • Twitter
    • Facebook
    • Pinterest
    • Instagram
    • YouTube
    Search

    Search

    BEE&YOU
    • All Products
    • Categories
      All Products
      • Tailored For You
        • For Athletes
        • For Travelers
        • For Kids & Family
        • For Healthy Aging
        • For Beauty Lovers
        • For Wellness Enthusiasts
        • For Busy Professionals
      • Health Essentials
        • Immune Boosters
        • Energy & Vitality
        • Skin & Beauty Care
        • Respiratory Support
        • Gut Health & Digestion
        • Joint & Muscle Care
        • Sleep & Relaxation
      Anatolian Propolis Extract (A.P.E)®

      Anatolian Propolis Extract (A.P.E)®

      Shop All
      SKIN CARE

      SKIN CARE

      Shop All
    • Propolis
    • Royal Jelly
    • Raw Honey
    • Bee Bread & Pollen
    • Skincare
    Search

    Search

    Account
    Log in Create Account
    Cart
    00 items
    Home
    Our Clinical Publications
    Evaluation of Turkish propolis for its chemical composition, antioxidant capacity, anti-proliferative effect on several human breast cancer cell lines and proliferative effect on fibroblasts and mouse mesenchymal stem cell line

    Evaluation of Turkish propolis for its chemical composition, antioxidant capacity, anti-proliferative effect on several human breast cancer cell lines and proliferative effect on fibroblasts and mouse mesenchymal stem cell line

    Updated on  January 23, 2023
    Evaluation of Turkish propolis for its chemical composition, antioxidant capacity, anti-proliferative effect on several human breast cancer cell lines and proliferative effect on fibroblasts and mouse mesenchymal stem cell line

    Abstract and Figures

    Propolis is an extremely complex resinous natural compound collected by honey bees from various plant sources and exhibits pharmacological and biological properties attributed to the presence of polyphenols. This study examined the total phenolic and flavonoid contents as well as the total antioxidant capacity using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), cupric-reducing antioxidant capacity (CUPRAC), and ferric-reducing antioxidant power (FRAP) methods. Turkish propolis has very high total phenolic (314.36 ± 3.65 mg GAE/g propolis) and total flavonoid contents (522.71 ± 11.45 mg QE/g propolis). The highest antioxidant capacity value was obtained by the CUPRAC method (1184.94 ± 63.27 mg TE/g propolis). Phenolic profile of Turkish propolis was also determined by high performance liquid chromatography with photodiode array detection (HPLC-PDA) method. The main phenolic compounds identified in Turkish propolis was flavonoids including pinocembrin > chrysin > galangin > pinobanksin > pinostrobin and phenolic acids including caffeic acid > p-coumaric acid > ferrulic acid > t-cinnamic acid. In the present work, anti-proliferative and proliferative effects of propolis extracts were also investigated on two different breast cancer cell lines; MDA-MB-231, UACC-3199 and on two normal cell lines; fibroblasts and mouse mesenchymal stem cell lines. According to the XTT results, Turkish propolis sample showed significant anti-proliferative effect on MDA-MB-231 and UACC breast cancer cell lines. Interestingly, Turkish propolis sample had proliferative effect on both fibroblasts and mouse mesenchymal stem cells. These results suggest that Turkish propolis can be considered as a potent agent on breast cancer treatment for further investigations. Evaluación del propóleos turco según su composición química, capacidad antioxidante, efecto antiproliferativo en varias líneas celulares de cáncer de mama humano y efecto proliferativo en fibroblastos y en la línea de células madre mesenquimales de ratones. El propóleos es un compuesto natural resinoso extremadamente complejo recogido por las abejas melíferas a partir de diversas fuentes vegetales, y presenta propiedades farmacológicas y biológicas atribuidas a la presencia de polifenoles. Este estudio examinó el contenido total de fenoles y flavonoides, así como la capacidad antioxidante total utilizando los métodos 2,2′-azino-bis(ácido 2,2′-etilbenzotiazolina-6-sulfónico (ABTS), 2,2-difenil-1-picrilhidrazilo (DPPH), capacidad antioxidante reductora de cúpricos (CUPRAC por sus siglas en inglés) y poder antioxidante reductor de férricos (FRAP por sus siglas en inglés). El propóleos turco tiene un contenido fenólico total muy alto (314,36 ± 3,65 mg GAE/g de propóleos) y un contenido flavonoide total (522,71 ± 11,45 mg QE/g de propóleos). El valor más alto de capacidad antioxidante se obtuvo con el método CUPRAC (1184.94 ± 63.27 mg TE/g propóleo). El perfil fenólico del propóleos turco también se determinó por cromatografía líquida de alta resolución con el método de detección de matriz de fotodiodos (HPLC-PDA). Los principales compuestos fenólicos identificados en el propóleos turco fueron los flavonoides, incluyendo pinocembrina > crisina > galangina > pinobanksina > pinostrobina y ácidos fenólicos, incluyendo ácido cafeico > ácido p-cumárico > ácido férrico > ácido t-cinámico. En el presente trabajo, también se investigó el efecto antiproliferativo y proliferativo de los extractos de propóleos en dos líneas celulares diferentes de cáncer de mama; MDA-MB-231, UACC-3199 y en dos líneas celulares normales; fibroblastos y líneas de células madre mesenquimales de ratones. Según los resultados del XTT, la muestra de propóleos turcos mostró un efecto antiproliferativo significativo en las líneas celulares de cáncer de mama MDA-MB-231 y UACC. Curiosamente, la muestra de propóleos turcos tuvo un efecto proliferativo tanto en los fibroblastos como en las células madre mesenquimales de ratones. Estos resultados sugieren que el propóleos turco puede ser considerado como un agente potente en el tratamiento del cáncer de mama para investigaciones posteriores.

    Read More: https://www.researchgate.net/publication/327934932_Evaluation_of_Turkish_propolis_for_its_chemical_composition_antioxidant_capacity_anti-proliferative_effect_on_several_human_breast_cancer_cell_lines_and_proliferative_effect_on_fibroblasts_and_mouse_m

    Featured Articles

    BEE&YOU Summer Essentials: Natural Mineral  Sunscreen and Deodorant That Truly Protect!

    BEE&YOU Summer Essentials: Natural Mineral Sunscreen and Deodorant That Truly Protect!

    Why Choosing the Right Sunscreen Matters: Protect Your Skin and the Planet with BEE&YOU Mineral Sunscreen

    Why Choosing the Right Sunscreen Matters: Protect Your Skin and the Planet with BEE&YOU Mineral Sunscreen

    Stay Strong This Winter with BEE&YOU’s Natural Immune Boosters

    Stay Strong This Winter with BEE&YOU’s Natural Immune Boosters

    Company
    • About Us
    • News from Us
    • Our Podcasts
    • Awards
    • Certificates
    • Our Clinical Publications
    • Analysis
    • Our History
    • Blog
    • Become an Affiliate
    • Become a Dietitian Affiliate
    Company
    • About Us
    • News from Us
    • Our Podcasts
    • Awards
    • Certificates
    • Our Clinical Publications
    • Analysis
    • Our History
    • Blog
    • Become an Affiliate
    • Become a Dietitian Affiliate
    Customer Care
    • Contact
    • Our Environmental Policy
    • Food Assurance Policy
    • Social Responsibility Policy
    • Terms of Service
    • Terms & Conditions for Subscription
    • T & C for Affiliate Program
    • Shipping Policy
    • Privacy Policy
    • Return Policy
    • Refund Policy
    Customer Care
    • Contact
    • Our Environmental Policy
    • Food Assurance Policy
    • Social Responsibility Policy
    • Terms of Service
    • Terms & Conditions for Subscription
    • T & C for Affiliate Program
    • Shipping Policy
    • Privacy Policy
    • Return Policy
    • Refund Policy
    Useful Information
    • WHAT IS PROPOLIS ?
    • WHAT IS ROYAL JELLY?
    • WHY BEE BREAD IS HEALTHY
    • WHAT IS ANATOLIAN BEE PROPOLIS?
    • WHAT IS BEE POLLEN?
    • BENEFITS OF BEE VENOM ON THE SKIN
    • NATURAL SECRET OF SKIN HEALTH AND BEAUTY
    • PROPOLIS NASAL SPRAY
    Useful Information
    • WHAT IS PROPOLIS ?
    • WHAT IS ROYAL JELLY?
    • WHY BEE BREAD IS HEALTHY
    • WHAT IS ANATOLIAN BEE PROPOLIS?
    • WHAT IS BEE POLLEN?
    • BENEFITS OF BEE VENOM ON THE SKIN
    • NATURAL SECRET OF SKIN HEALTH AND BEAUTY
    • PROPOLIS NASAL SPRAY
    BEE&YOU
    © Copyright, BEE&YOU 2025 Powered by Shopify
    • United States (USD $)
    We Accept:
    • Amazon
    • American Express
    • Apple Pay
    • Diners Club
    • Discover
    • Google Pay
    • Mastercard
    • PayPal
    • Shop Pay
    • Venmo
    • Visa
    • Twitter
    • Facebook
    • Pinterest
    • Instagram
    • YouTube
    Subscribe to Our Newsletter and Get a special Offer

    Cart

    0 items

    Your Cart is Empty

    Loading...

    Shop Now
    • Choosing a selection results in a full page refresh.