Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms

This large-scale, prospective multicenter observational study evaluated the efficacy of a nasal spray formulation combining hypertonic saline with Anatolian propolis (brand: Rhinapi) in the management of allergic rhinitis symptoms. A total of about 10,000 participants (5,028 male, 4,972 female) across multiple centres in Turkey, all presenting with nasal discharge, sneezing, nasal itching or obstruction, were enrolled between March 2022 and March 2023. Patients administered one puff of Rhinapi into each nostril three times daily for three weeks. Major outcomes included total symptom score (sum of four key nasal symptoms), quality of life (QoL) score, and otolaryngologic examination findings (turbinate colour and edema). Results showed statistically significant improvements: the mean total symptom score decreased from 11.09 ± 3.41 before treatment to 6.23 ± 2.41 after three weeks (P < 0.001). Likewise, the average QoL score improved from 6.44 ± 1.55 to 7.31 ± 1.24 (P < 0.001). Turbinate colour and edema scores also showed significant positive changes (P < 0.001). The authors conclude that the Rhinapi spray may meaningfully reduce the symptom burden of allergic rhinitis and improve patient quality of life when used alongside conventional treatments.